Famciclovir Once 500mg

Regular price
$32.99
Sale price
$32.99
Regular price
Sold out
Unit price
per 
Tax included.
- +

Name of Medicine FAMVIR® ONCE Famciclovir 500 mg tablets Presentation White, oval, biconvex film-coated tablets, debossed with “FV 500” on one side and no markings on the reverse side. Uses Actions Pharmacotherapeutic group: Oral antiviral agent, ATC code: J05A B09 Famciclovir is the oral prodrug of penciclovir. Famciclovir is rapidly converted in vivo into penciclovir, which has demonstrable in vitro activity against herpes simplex viruses (HSV types 1 and 2), and varicella zoster virus (VZV). The antiviral effect of orally administered famciclovir has been demonstrated in several animal models: this effect is due to in vivo conversion to penciclovir. Penciclovir targets virus-infected cells where it is rapidly converted into penciclovirtriphosphate (mediated via virus-induced thymidine kinase). The triphosphate inhibits viral DNA polymerase by competition with deoxyguanosine triphosphate and is incorporated into the extending DNA chain, preventing significant chain elongation. Consequently, viral DNA synthesis and, therefore, viral replication are inhibited. This triphosphate persists in infected cells in excess of 12 hours. The long intracellular halflife of penciclovir triphosphate ensures prolonged antiviral activity, as demonstrated in cell cultures with HSV-1 and HSV-2 and in animal studies. Penciclovir is only readily phosphorylated in virus-infected cells. In uninfected cells treated with penciclovir, concentrations of penciclovir-triphosphate are only barely detectable. Accordingly, uninfected cells are unlikely to be affected by therapeutic concentrations of penciclovir. The most common form of resistance encountered with aciclovir among HSV strains is a deficiency in the production of the thymidine kinase (TK) enzyme. Such TK deficient strains would be expected to be cross-resistant to both penciclovir and aciclovir. However, penciclovir has been shown to be active against a clinically isolated aciclovir-resistant herpes simplex type 1 strain with an altered DNA polymerase. The results from penciclovir and famciclovir patient studies, including studies of up to four months’ treatment with famciclovir, showed that no resistance occurred as a result of treatment with either famciclovir or penciclovir. Penciclovir-resistant isolates were found at the start of treatment or in the placebo groups in 0.25% of the 1976 total isolates from HSV and VZV (5/1976), and in 0.19% of the 533 virus isolates from immunocompromised patients
Famciclovir Once 500mg - Corner Pharmacy